
HOW DOES IT WORK
How does it work and how is it possible?
This will explain how Quercetin/ Flavonoids work:
Quercetin is an antioxidant. It neutralizes free radicals. In doing this, Quercetin converts into a radical molecule. For example, it neutralizes 2 radical molecules and becomes a radical molecule with 2 radicals.
Then it covalently binds to a DNA molecule. Because there is no water present there, it remains as a radical molecule.
When a cell divides, water approaches this molecule, so it reacts with water causing OH radicals, thereby killing the cell.
Normal cells always repair their entire DNA before cell division, so the radical flavonoid molecule is always removed. So normal cells remain unharmed.
Cancer cells divide before repairing their entire DNA, so they die.
So it's actually a bomb.
A flavonoid molecule is like a bomb that explodes if it's not removed before a cell tries to divide. Cancer cells that divide before reparation die; this happens because the bomb wasn't removed, so it explodes when the cell tries to divide. Normal cells that divide after reparation remove the bomb, so they continue to live.
Cancer cells that do completely repair their DNA before cell division aren't cancer cells anymore (they are normal cells) because they have to wait a long time before cell division.
Normal cells that did not completely repair their DNA before cell division can transfer a mutation to their daughter cells.
So flavonoids kill only cancer cells but not normal cells.
It goes like this:
Normal cell -> completely repaired -> flavonoid bomb removed -> cell divides normally.
Cancer cell -> not completely repaired -> flavonoid bomb explodes -> cell dies during division.
Cancer cell that completely repairs = normal cell.
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This is a 100% cure for cancer! Because it kills all cancer cells and all normal cells remain, the cancer patient cures of cancer!
Mechanism Overview:
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Antioxidant Activity and Radical Formation: Quercetin is a well-known antioxidant that neutralizes harmful free radicals by donating electrons. In the process, Quercetin itself becomes a relatively stable radical due to its conjugated aromatic system, typically holding a single unpaired electron. This radical form of Quercetin remains chemically inert under normal cellular conditions.
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DNA Intercalation: Once in its radical form, Quercetin can intercalate between the base pairs of DNA due to its planar structure. The hydrophobic environment between DNA base pairs isolates the radical Quercetin molecule from water and other reactive species, stabilizing it within the DNA helix.
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Stability in Non-Dividing Cells: In non-dividing cells, DNA is tightly packed within chromatin, and the nuclear envelope limits water and reactive species from reaching the intercalated Quercetin radical. Additionally, normal cells have robust DNA repair mechanisms that can recognize and remove foreign molecules like the Quercetin adduct during repair processes, preventing potential damage.
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Exposure During Cell Division: During mitosis, the nuclear envelope dissolves, and chromatin becomes more exposed. This structural change allows water molecules to access the previously shielded Quercetin radical. In cancer cells, which often divide rapidly and with incomplete DNA repair, the Quercetin adduct remains lodged in the DNA during this phase.
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Radical Activation and Hydroxyl Radical Formation: Upon exposure to water during cell division, the Quercetin radical reacts with water molecules, leading to the production of highly reactive hydroxyl radicals (•OH). This reaction can be represented as:
Q• + H2O → QH + •OH
The hydroxyl radicals generated are highly damaging, causing breaks and distortions in the DNA structure, ultimately leading to apoptosis or necrosis of the cancer cell.
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Selective Cytotoxicity: Normal cells, due to their slower division rates and effective DNA repair systems, are more likely to remove the Quercetin adduct before division, avoiding damage. In contrast, cancer cells, with their rapid division and impaired repair mechanisms, fail to remove the adduct, triggering lethal DNA damage during mitosis.
Conclusion:
This mechanism positions Quercetin as a potential selective anti-cancer agent, functioning as a molecular "bomb" that activates only in cancer cells during division. By exploiting the fundamental differences in DNA repair and cell cycle regulation between healthy and cancerous cells, Quercetin offers a targeted approach to induce cancer cell death while preserving normal tissue integrity.